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Vomiting: This occurs more often with semaglutide, affecting 21% of people compared to 15% with tirzepatide
Management strategies: Keep doses at 100 mcg per injection If prolactin-related symptoms emerge, vitamin B6 (P-5-P form, 50-100 mg daily) can help More significant prolactin elevation may require pharmaceutical management with a healthcare provider Consider switching to ipamorelin, which does not significantly elevate prolactin at any dose Water retention and joint effects The elevated GH levels produced by GHRP-6 can cause fluid retention, manifesting as bloating, puffiness (particularly in the face and extremities), and joint stiffness
Research suggests supplementation (including 300 mg/day orally) might improve liver enzyme labs in people with fatty liver disease (Healthline)
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